Mapping Pathways is a multi-national project to develop and nurture a research-driven, community-led global understanding of the emerging evidence base around the adoption of antiretroviral-based prevention strategies to end the HIV/AIDS epidemic. The evidence base is more than results from clinical trials - it must include stakeholder and community perspectives as well.

09 June 2011

Treatment as Prevention: Protecting patient autonomy

via POZ, by Joseph Sonnabend, M.D.

Patient autonomy is just a particular instance of individual autonomy, a term that may sound pretty dry and academic but if we used the term individual freedom we would essentially be talking about the same thing.

Respect for the autonomy of the individual may be the most important of the principles that form the foundation of medical ethics. (1)

One attribute of personal autonomy is: "the capacity to be one's own person, to live one's life according to reasons and motives that are taken as one's own and not the product of manipulative or distorting external forces." (2)

There is no disagreement about the importance of respect for individual autonomy but as I'll explain, it seems that its pre-eminence is being questioned in some proposals to use antiretroviral treatment to prevent transmission of HIV.

The recent demonstration that antiretroviral treatment can prevent transmission of HIV among serodiscordant heterosexual couples is great news. However, when the person offered treatment has not yet been shown to personally benefit from it, an ethical issue needs to be addressed. This is because it has yet to be reliably shown that for people with greater than 350 CD4 lymphocytes, starting treatment immediately rather than deferring it confers a net benefit; indeed, it may even prove to be harmful. START is a randomized controlled trial now enrolling that will provide needed information, but we will have to wait several years for its results. The issue isn't whether people with greater than 350 CD4 lymphocytes should or should not receive treatment. A respect for their autonomy means that the decision whether or not to do so is made by them and is made free from coercion.

Read the rest.


[Content that is linked from other sources is for informational purposes and should not construe a Mapping Pathways position.]

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