NIH to test maraviroc-based drug regimens for HIV prevention

via National Institute of Health

Scientists are launching the first clinical trial to test whether drug regimens containing maraviroc, a medication currently approved to treat HIV infection, are also safe and tolerable when taken once daily by HIV-uninfected individuals at increased risk for acquiring HIV infection.

The eventual goal is to see if the drug regimens can reduce the risk of infection.

The trial involves a strategy known as pre-exposure prophylaxis, or PrEP, in which HIV-uninfected individuals who are at risk for contracting the virus take one or two HIV drugs routinely in an effort to prevent infection. Called Novel Exploration of Therapeutics for PrEP, or NEXT-PrEP, the two-year study is sponsored and funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

"The NEXT-PrEP study will examine whether maraviroc-based PrEP is safe and well-tolerated. It is a necessary first step before we can test the effectiveness of maraviroc-based PrEP, and in the future, potentially expand the selection of drugs that may be used in this emerging HIV prevention strategy," said NIAID Director Anthony S. Fauci, M.D.

Led by principal investigator Roy M. Gulick, M.D., M.P.H., chief of the Division of Infectious Diseases and professor of medicine at Weill Cornell Medical College of Cornell University, the study team will enroll 400 HIV-uninfected men who have sex with men (MSM) ages 18 and older in 12 cities in the United States and Puerto Rico.

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San Francisco to roll out PrEP for gay men

via Bay Area Reporter, by Matthew S. Bajko

San Francisco is expected to become the first city in the country to offer gay men an anti-HIV pill that has proven successful in stopping transmission of the virus that causes AIDS.

Officials with the National Institutes of Health and San Francisco public health officials are close to finalizing an agreement to launch in early 2012 a demonstration project for usage of pre-exposure prophylaxis or PrEP. The combination pill contains tenofovir and emtricitabine (Gilead Science's Truvada) and has proven to be highly effective during clinical trials studying its efficacy.

Under the contract, up to 300 men who have sex with men at high risk for contracting HIV would be enrolled in the pilot study. City Clinic would administer the program while Magnet, the gay men's health center in the Castro, would help identify suitable participants for the study.

"We are anticipating we will be the first municipality to implement a PrEP demonstration project and things are moving forward toward that goal," Dr. Grant Colfax, the city's director of HIV prevention, told the Bay Area Reporter this week. "We are hoping the demo project would be implemented in the first quarter of 2012."


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Reuters: 30 years on, AIDS fight may tilt more to treatment

via Reuters, by Julie Steenhuysen and Barbara Lewis

After 30 years of AIDS prevention efforts, global leaders may now need to shift their focus to spending more on drugs used to treat the disease as new data show this is also the best way to prevent the virus from spreading.

The U.N. General Assembly will take up the issue [this] week as it assesses progress in fighting the disease -- first reported on June 5, 1981 -- that has infected more than 60 million people and claimed nearly 30 million lives.

Guiding the meeting is groundbreaking new data that shows early treatment of the human immunodeficiency virus, or HIV, can cut its transmission to a sexual partner by 96 percent.

"There had been for a long time this artificial dichotomy or artificial tension between treatment versus prevention. Now it is very clear that treatment is prevention and treatment is an important part of a multifaceted combination strategy," Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases division of the National Institutes of Health (NIH), told Reuters.

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